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Wisconsin Democrats look ahead to November
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Democrats in Wisconsin, fresh off the primary, are looking ahead to November. They held a "United Rally" in Milwaukee. (Aug. 11) (AP video: Carrie Antlfinger)
Is Home Blood Pressure Monitoring Effective at Controlling Hypertension in African American Patients? A Clin-IQ
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African Americans are disproportionately affected by hypertension, a modifiable contributor to multiple chronic diseases and premature death. Primary care physicians play an important role in hypertension control. Home blood pressure monitoring (HBPM) is an evidence-based method for confirming diagnosis and monitoring hypertension over time. Some...
Neurological Manifestations of SARS-CoV-2 Infection: Protocol for a Sub-analysis of the COVID-19 Critical Care...
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INTRODUCTION: Neurological manifestations and complications in coronavirus disease-2019 (COVID-19) patients are frequent. Prior studies suggested a possible association between neurological complications and fatal outcome, as well as the existence of potential modifiable risk factors associated to their occurrence. Therefore, more information is...
The long and winding road: From mouse linkage studies to a novel human therapeutic pathway in type 1 diabetes
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Autoimmunity involves a loss of immune tolerance to self-proteins due to a combination of genetic susceptibility and environmental provocation, which generates autoreactive T and B cells. Genetic susceptibility affects lymphocyte autoreactivity at the level of central tolerance (e.g., defective, or incomplete MHC-mediated negative selection of...
Control of a Wheelchair-Mounted 6DOF Assistive Robot With Chin and Finger Joysticks
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Throughout the last decade, many assistive robots for people with disabilities have been developed; however, researchers have not fully utilized these robotic technologies to entirely create independent living conditions for people with disabilities, particularly in relation to activities of daily living (ADLs). An assistive system can help satisfy...
Heterologous production of the adhesin LIC13411 from pathogenic Leptospira facilitates binding of non-pathogenic...
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Leptospirosis is an important cause of morbidity and mortality worldwide. Disease severity ranges from asymptomatic colonization to widespread hemorrhage and multiorgan dysfunction. The causative agents, Leptospira spp., are zoonotic Gram-negative spirochetes. One important step in pathogenesis is binding of bacterial adhesins to host components.
Republicans pick Milwaukee to host 2024 convention
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Republicans have unanimously chosen Milwaukee in swing state Wisconsin to host the 2024 national convention, beating out Nashville in deep-red Tennessee. (Aug. 5)
Neighborhood Socioeconomic Disadvantage and the Neurobiology of Uncertainty in Traumatically Injured Adults
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CONCLUSIONS: Together, these results may represent an adaptive response to predictable and/or negative stimuli, stemming from chronic exposure to socioeconomic-based uncertainties. Although effects were modest, future work should continue to examine pretrauma context on posttrauma outcomes. To better understand trauma outcomes, it is imperative...
Trends and Racial/Ethnic Differences in Health Care Spending Stratified by Gender among Adults with Arthritis in the...
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The purpose of this study was to determine if there were racial/ethnic differences and patterns for individual office-based visit expenditures by gender among a nationally representative sample of adults with arthritis. We retrospectively analyzed pooled data from the 2011 to 2019 Medical Expenditure Panel Survey of adults who self-reported an...
Myeloperoxidase as a Marker to Differentiate Mouse Monocyte/Macrophage Subsets
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Macrophages are present in every tissue in the body and play essential roles in homeostasis and host defense against microorganisms. Some tissue macrophages derive from the yolk sac/fetal liver that populate tissues for life. Other tissue macrophages derive from monocytes that differentiate in the bone marrow and circulate through tissues via the...
The Sensory Auricular Branch of the Facial Nerve and its Relationship to Landmarks of the Facial Recess
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CONCLUSION: Recognizing the SAB and knowing its relationships to surrounding anatomy provides a useful adjunctive landmark for the identification of the main trunk of the facial nerve's mastoid segment.
Intraarterial Therapies for the Management of Hepatocellular Carcinoma
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Image-guided locoregional therapies play a crucial role in the management of patients with hepatocellular carcinoma (HCC). Transarterial therapies consist of a group of catheter-based treatments where embolic agents are delivered directly into the tumor via their supplying arteries. Some of the transarterial therapies available include bland...
Serum Concentrations of the Endocannabinoid, 2-Arachidonoylglycerol, in the Peri-Trauma Period Are Positively Associated...
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Endocannabinoid signaling and the hypothalamic-pituitary-adrenal axis are activated by trauma and both stress systems regulate the transition from acute to chronic pain. This study aimed to develop a model of relationships among circulating concentrations of cortisol and endocannabinoids (eCBs) immediately after traumatic injury and the presence of...
Novel Genetic Diagnoses in Septo-Optic Dysplasia
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Septo-optic dysplasia (SOD) is a developmental phenotype characterized by midline neuroradiological anomalies, optic nerve hypoplasia, and pituitary anomalies, with a high degree of variability and additional systemic anomalies present in some cases. While disruption of several transcription factors has been identified in SOD cohorts, most cases...
Emerging Roles and Potential Applications of Non-Coding RNAs in Cervical Cancer
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Cervical cancer (CC) is a preventable disease using proven interventions, specifically prophylactic vaccination, pervasive disease screening, and treatment, but it is still the most frequently diagnosed cancer in women worldwide. Patients with advanced or metastatic CC have a very dismal prognosis and current therapeutic options are very limited.
Latent Class Analysis of Polysubstance Use and Sexual Risk Behaviors among Men Who Have Sex with Men Attending Sexual...
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CONCLUSIONS: Attempts to detect alcohol and problematic use of substances are needed for MSM followed by culturally competent approaches that address alcohol and drug use disorders.
Treatment of Mantle Cell Lymphoma in the Frontline Setting: Are We Ready for a Risk-Adapted Approach?
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Mantle cell lymphoma (MCL), a type of B-cell non-Hodgkin lymphoma characterized by the t(11;14)(q13q32) translocation, is a clinically heterogenous disease which can range from indolent to highly aggressive. Numerous prognostic factors have been identified, including blastoid histology, the Mantle Cell Lymphoma International Prognostic Index (MIPI)...
Decreased Left Atrial Reservoir Strain Is Associated with Adverse Outcomes in Restrictive Cardiomyopathy
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CONCLUSIONS: The decreased LA reservoir strain is independently associated with time to adverse events in patients with RCM.
A Rare Case of Neck Sarcomatoid Squamous Cell Carcinoma With Brain Metastases
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Squamous cell carcinoma (SCC) is the second most prominent form of skin malignancy. It occurs most frequently in older males with fair skin complexion that have extensive sun exposure most commonly in their childhood. The metastatic presentation of SCC is rare and is most common in the lung. In this paper, we present the unique case of a...
Evaluation of liver transplant candidates with non-alcoholic steatohepatitis
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Non-alcoholic steatohepatitis (NASH) is anticipated to become the leading indication for liver transplantation (LT) in the United States in the near future. LT is indicated in patients with NASH-related cirrhosis who have medically refractory hepatic decompensation, synthetic dysfunction, and hepatocellular carcinoma (HCC) meeting certain criteria.
Comparative Efficacy Randomized Controlled Trials in Rheumatology Guidelines
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CONCLUSION: Less than one in six rheumatology guideline recommendations are informed by head-to-head RCTs. Recommendations that were informed by head-to-head RCTs were more likely to have a high LOE by both GRADE and OCEBM. Efforts to introduce more comparative efficacy RCTs should be undertaken.
CB2 Agonist GW842166x Protected against 6-OHDA-Induced Anxiogenic- and Depressive-Related Behaviors in Mice
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In addition to motor dysfunction, patients with Parkinson's disease (PD) are often affected by neuropsychiatric disorders, such as anxiety and depression. In animal models, activation of the endocannabinoid (eCB) system produces anxiolytic and antidepressant-like behavioral effects. CB2 agonists have demonstrated neuroprotective effects against...
2022-2030 Report on Global Core Drill Market by Player, Region, Type, Application and Sales Channel
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This report studies the Core Drill market, covering market size for segment by type (Wet Drill Bits, Dry Drill Bits, etc.), by application (Construction Industry, Renovation Industry, etc.), by sales channel (Direct Channel, Distribution Channel), by player (Hilti, Husqvarna, Makita, Tyrolit, Robert Bosch, etc.) and by region (North America,...
Genetically detoxified tetanus toxin as a vaccine and conjugate carrier protein
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Tetanus toxoid (TTxd), developed over 100 years ago, is a clinically effective, legacy vaccine against tetanus. Due to the extreme potency of native tetanus toxin, manufacturing and regulatory efforts often focus on TTxd production, standardization, and safety, rather than product modernization. Recently, a genetically detoxified, full-length...
Health Related Quality of Life in Young Adults Survivors of Hematopoietic Cell Transplantation
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CONCLUSIONS: Overall, young adult HCT survivors have lower mental health, increased cancer-related distress, and lower levels of HSE compared to older adults. Although the direction of these effects cannot be determined with these data, the strong association between HSE and HRQOL among young adults suggests that targeting interventions to improve...